Projects (2015-2019)

1. Small ligands to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers

2. Pepducins to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers

3. Nanobodies/antibodies to modulate and detect CXCR4 and CXCR7 mono-, homo-, and heteromers  

4. Development of CXCR4 and CXCR7 specific chemokines and reagents 

5. In silico guided identification of molecular determinants for modulation of CXCR4 and CXCR7

6. Functional properties of CXCR4 and CXCR7 homo- and heteromers

7. G protein-dependent signalling by CXCR4 and CXCR7

8. Role of G protein-coupled receptor kinases (GRKs) in CXCR4 and CXCR7 signalling and modulation 

9. Analysis of biased signalling responses through CXCR4 and CXCR7 

10. Differential phosphorylation of CXCR4 and CXCR7 

11. Localization and trafficking of CXCR4 and CXCR7 

12. Functional proteomics of CXCR4 and CXCR7-associated signalling networks 

13. Development of (patho)physiological in vitro and in vivo models to assess effect of CXCR4/CXCR7 modulators

14. Genetic mouse models and in vivo studies

15. In situ analysis of CXCR4 and CXCR7 ligand-binding and spatio-temporal localization using imaging tools on ex vivo samples

All positions are filled

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ONCORNET2.0 Follow

ONCOgenic GPCR Network of Excellence and Training. An #EU Marie-Curie ITN of 16 Early Stage Researchers studying CXCR4 and ACKR3 #chemokine #GPCRs in cancer

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Avatar ONCORNET2.0 @oncornet1 ·
5 Nov

Great way to finish the week off with some #FCS measurements of CXCR4-expressing HEK cells at @UoNLifeSci 🔬 #FluorescenceFriday

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Avatar ONCORNET2.0 @oncornet1 ·
20 Oct

Hello everyone!
I am Noemi Karsai and I’m the next in our #ESR introduction series. I’m #ESR11 and I’m originally from Hungary, currently doing my PhD at @UoNLifeSci @COMPARE_UoBUoN, UK.

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Avatar ONCORNET2.0 @oncornet1 ·
8 Jul 2021

The transatlantic ECI GPCR symposium #ECIGPCR is about to start, we are ready!! Thanks to the organizers for their excellent job gathering almost 500 people across the globe! @cyclic_Andreas @NicoleAPerry1 @BenderSci @DesislavaNeshe1

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Avatar ONCORNET2.0 @oncornet1 ·
29 Jun 2021

Hello 🙂
I am here to continue the series in which all #ESRs are presenting themselves. I am Viviana Marolda and I am in my first year of PhD. I am #ESR13, originally from Italy, and currently, I am working as a PhD student in @CBMSO_CSIC_UAM, at Universidad Autonoma de Madrid.

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Avatar ONCORNET2.0 @oncornet1 ·
14 Jun 2021

Hey twitter!
I am @DehanComez. I am taking over the Oncornet account for a while to start a series of all #ESRs writing about themselves and their projects. I am #ESR5, originally from Turkey and right now I am working as a PhD student in @COMPARE_UoBUoN , @UniofNottingham , UK.

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Avatar David Gloriam @david_gloriam ·
28 May 2021

New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond https://lnkd.in/eyjrA5V

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Avatar ONCORNET2.0 @oncornet1 ·
28 May 2021

ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function: https://molpharm.aspetjournals.org/content/96/6

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Avatar ONCORNET2.0 @oncornet1 ·
28 May 2021

Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!

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Contact details

Please contact us at:
info@oncornet.eu

ONCORNET Coordinator
VU University Amsterdam
The Netherlands

Funded by

Marie Curie Actions

EU Horizon 2020

European Union