Projects (2015-2019)

1. Small ligands to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers

2. Pepducins to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers

3. Nanobodies/antibodies to modulate and detect CXCR4 and CXCR7 mono-, homo-, and heteromers

4. Development of CXCR4 and CXCR7 specific chemokines and reagents

5. In silico guided identification of molecular determinants for modulation of CXCR4 and CXCR7

6. Functional properties of CXCR4 and CXCR7 homo- and heteromers

7. G protein-dependent signalling by CXCR4 and CXCR7

8. Role of G protein-coupled receptor kinases (GRKs) in CXCR4 and CXCR7 signalling and modulation

9. Analysis of biased signalling responses through CXCR4 and CXCR7

10. Differential phosphorylation of CXCR4 and CXCR7

11. Localization and trafficking of CXCR4 and CXCR7

12. Functional proteomics of CXCR4 and CXCR7-associated signalling networks

13. Development of (patho)physiological in vitro and in vivo models to assess effect of CXCR4/CXCR7 modulators

14. Genetic mouse models and in vivo studies

15. In situ analysis of CXCR4 and CXCR7 ligand-binding and spatio-temporal localization using imaging tools on ex vivo samples

All positions are filled

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Contact details

Please contact us at:
e.v.langemeijer@vu.nl

ONCORNET Coordinator
Vrije Universiteit Amsterdam

Funded by

Marie Curie Actions

EU Horizon 2020