Projects (2015-2019)

1. Small ligands to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers

2. Pepducins to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers

3. Nanobodies/antibodies to modulate and detect CXCR4 and CXCR7 mono-, homo-, and heteromers  

4. Development of CXCR4 and CXCR7 specific chemokines and reagents 

5. In silico guided identification of molecular determinants for modulation of CXCR4 and CXCR7

6. Functional properties of CXCR4 and CXCR7 homo- and heteromers

7. G protein-dependent signalling by CXCR4 and CXCR7

8. Role of G protein-coupled receptor kinases (GRKs) in CXCR4 and CXCR7 signalling and modulation 

9. Analysis of biased signalling responses through CXCR4 and CXCR7 

10. Differential phosphorylation of CXCR4 and CXCR7 

11. Localization and trafficking of CXCR4 and CXCR7 

12. Functional proteomics of CXCR4 and CXCR7-associated signalling networks 

13. Development of (patho)physiological in vitro and in vivo models to assess effect of CXCR4/CXCR7 modulators

14. Genetic mouse models and in vivo studies

15. In situ analysis of CXCR4 and CXCR7 ligand-binding and spatio-temporal localization using imaging tools on ex vivo samples

All positions are filled

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Retweet on TwitterONCORNET2.0 Retweeted
AvatarDavid Gloriam@David_Gloriam·
28 May

New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond https://lnkd.in/eyjrA5V

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AvatarONCORNET2.0@ONCORNET1·
28 May

ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function: https://molpharm.aspetjournals.org/content/96/6

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AvatarONCORNET2.0@ONCORNET1·
28 May

Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!

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AvatarSteve Briddon🧪🔬📷🎧💙@Hebdomadian·
18 May

Hi everyone!

Public service announcement: our Marie-Curie ITN @ONCORNET1 is on Twitter! The 16 wonderful #ECRs working on the project will soon be Tweeting about #GPCR #chemokine #ECR life and #pharmacology

Please #RT & consider a follow or follow back! 🙏😀

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Contact details

Please contact us at:
info@oncornet.eu

ONCORNET Coordinator
VU University Amsterdam
The Netherlands

Funded by

Marie Curie Actions

EU Horizon 2020

European Union