Projects (2015-2019)
1. Small ligands to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers
2. Pepducins to modulate CXCR4 and CXCR7 mono-, homo-, and heteromers
3. Nanobodies/antibodies to modulate and detect CXCR4 and CXCR7 mono-, homo-, and heteromers
4. Development of CXCR4 and CXCR7 specific chemokines and reagents
5. In silico guided identification of molecular determinants for modulation of CXCR4 and CXCR7
6. Functional properties of CXCR4 and CXCR7 homo- and heteromers
7. G protein-dependent signalling by CXCR4 and CXCR7
8. Role of G protein-coupled receptor kinases (GRKs) in CXCR4 and CXCR7 signalling and modulation
9. Analysis of biased signalling responses through CXCR4 and CXCR7
10. Differential phosphorylation of CXCR4 and CXCR7
11. Localization and trafficking of CXCR4 and CXCR7
12. Functional proteomics of CXCR4 and CXCR7-associated signalling networks
14. Genetic mouse models and in vivo studies
All positions are filled
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My project will be focused on the role of #CXCR4/ACKR3/GRK2 -governed networks in cancer cell migration and metastasis.
New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond https://lnkd.in/eyjrA5V
A reminder that applications for our new Deputy Editor in Chief of #PharmacologyMatters close on Monday. https://buff.ly/2PNWf4V
ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function: https://molpharm.aspetjournals.org/content/96/6
Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!
Contact details
Please contact us at:
info@oncornet.eu
ONCORNET Coordinator
VU University Amsterdam
The Netherlands