Projects (2020-2024)

1. Photoactivatable ligand tools for CXCR4 and ACKR3

2. Nanobodies as modulators of CXCR4/ACKR3/RTK function

3. Functioning and structure of CXCR4/ACKR3/CCR5 oligomeric complexes

4. Basis and molecular consequences of interactions between adrenomedullin and ACKR3 /CXCR4

5. Spatial organisation of CXCR4 and ACKR3 receptors and complexes with growth factor receptors

6. Super-resolution spatiotemporal analysis of CXCR4/ACKR3 signalling nanodomains

7. Pharmacological analysis of photoactivatable CXCR4/ACKR3 ligands in vitro/in vivo

8. Conformational signature of CXCR4/ACKR3 activation in β-arrestin-1 and -2

9. Functional proteomics of native CXCR4 and ACKR3-operated signalling

10. Functional consequences phosphorylation barcoding/oligomerization CXCR4 and ACKR3

11. Compartmentalised signalling and trafficking of CXCR4 and ACKR3

12. A systems biology approach to analyse signalling and trafficking patterns of CXCR4 and ACKR3

13. CXCR4/ACKR3/GRK2-governed networks in cancer cell migration and metastasis

14. CXCR4-ACKR3 (patho)physiological roles in human papillomavirus (HPV) oncogenesis: controlling the shift from commensalism to pathogenesis

15. Ambidextrous value (co)creation

16. Multidimensional regulation of the opioid network by ACKR3

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Contact details

Please contact us at:
e.v.langemeijer@vu.nl

ONCORNET Coordinator
Vrije Universiteit Amsterdam

Funded by

Marie Curie Actions

EU Horizon 2020