Projects (2020-2024)
1. Photoactivatable ligand tools for CXCR4 and ACKR3
2. Nanobodies as modulators of CXCR4/ACKR3/RTK function
3. Functioning and structure of CXCR4/ACKR3/CCR5 oligomeric complexes
4. Basis and molecular consequences of interactions between adrenomedullin and ACKR3 /CXCR4
5. Spatial organisation of CXCR4 and ACKR3 receptors and complexes with growth factor receptors
6. Super-resolution spatiotemporal analysis of CXCR4/ACKR3 signalling nanodomains
7. Pharmacological analysis of photoactivatable CXCR4/ACKR3 ligands in vitro/in vivo
8. Conformational signature of CXCR4/ACKR3 activation in β-arrestin-1 and -2
9. Functional proteomics of native CXCR4 and ACKR3-operated signalling
10. Functional consequences phosphorylation barcoding/oligomerization CXCR4 and ACKR3
11. Compartmentalised signalling and trafficking of CXCR4 and ACKR3
12. A systems biology approach to analyse signalling and trafficking patterns of CXCR4 and ACKR3
13. CXCR4/ACKR3/GRK2-governed networks in cancer cell migration and metastasis
15. Ambidextrous value (co)creation
16. Multidimensional regulation of the opioid network by ACKR3
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Contact details
Please contact us at:
e.v.langemeijer@vu.nl
ONCORNET Coordinator
Vrije Universiteit Amsterdam