Projects (2020-2024)
1. Photoactivatable ligand tools for CXCR4 and ACKR3
2. Nanobodies as modulators of CXCR4/ACKR3/RTK function
3. Functioning and structure of CXCR4/ACKR3/CCR5 oligomeric complexes
4. Basis and molecular consequences of interactions between adrenomedullin and ACKR3 /CXCR4
5. Spatial organisation of CXCR4 and ACKR3 receptors and complexes with growth factor receptors
6. Super-resolution spatiotemporal analysis of CXCR4/ACKR3 signalling nanodomains
7. Pharmacological analysis of photoactivatable CXCR4/ACKR3 ligands in vitro/in vivo
8. Conformational signature of CXCR4/ACKR3 activation in β-arrestin-1 and -2
9. Functional proteomics of native CXCR4 and ACKR3-operated signalling
10. Functional consequences phosphorylation barcoding/oligomerization CXCR4 and ACKR3
11. Compartmentalised signalling and trafficking of CXCR4 and ACKR3
12. A systems biology approach to analyse signalling and trafficking patterns of CXCR4 and ACKR3
13. CXCR4/ACKR3/GRK2-governed networks in cancer cell migration and metastasis
15. Ambidextrous value (co)creation
16. Multidimensional regulation of the opioid network by ACKR3
Follow us on
My project will be focused on the role of #CXCR4/ACKR3/GRK2 -governed networks in cancer cell migration and metastasis.
New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond https://lnkd.in/eyjrA5V
A reminder that applications for our new Deputy Editor in Chief of #PharmacologyMatters close on Monday. https://buff.ly/2PNWf4V
ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function: https://molpharm.aspetjournals.org/content/96/6
Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!
Contact details
Please contact us at:
info@oncornet.eu
ONCORNET Coordinator
VU University Amsterdam
The Netherlands