University of Glasgow

Webpage: http://www.gla.ac.uk/researchinstitutes/biology and http://www.gla.ac.uk/researchinstitutes/iii/

General description
The ‘Molecular Pharmacology Group’ at the University of Glasgow is lead by Graeme Milligan and has been identified as one of the leading GPCR teams in the world. The team focuses on the pharmacology, structure and regulation of GPCRs and their interacting proteins and how the behaviour of GPCRs can be adapted to develop novel platforms for early stage drug discovery. The Molecular Pharmacology Group has published nearly 500 papers and their studies have been cited more than 16,000 times. The Chemokine Research Group (CRG) at the University of Glasgow is lead by Gerry Graham and represents one of the largest collections of chemokine researchers in Europe (www.chemokineresearchgroup.org). CRG has over 25 years of experience of working with chemokines and their receptors during which time it has made fundamental contributions to this important field. Most recently CRG researchers have been at the forefront of atypical chemokine receptor biology.

Key research facilities, infrastructures and equipment
UGLA is the lead academic partner for an ‘Innovation centre’ in personalised medicine using next generation genomic sequencing and analysis to promote personalised medicine and decrease attrition potential withdrawal of medicines. The Molecular Pharmacology Group is underpinned by state of the art facilities including the Glasgow Polyomics Facility that provides a full array of genomic, transcriptomic, proteomic and metabolomic analyses. High-end imaging capabilities allow millisecond kinetic analysis of ligand binding and debinding from GPCRs. Physiological outcomes of GPCR activation are integrated into the work via direct links with the Cardiovascular and Medical Sciences and Inflammation Research Institutes of the College of Medical, Veterinary and Life Sciences College of University of Glasgow. Collaborations with a wide range of companies within the pharmaceutical industry has resulted in a series of successful outcomes. The group has also trained many early career researchers who have subsequently moved to work for European SMEs. This includes both Heptares and Vivia who are partners within INSIGHT. The chemokine research group has expertise in receptor cloning and biochemistry as well as in advanced and complex animal models of chemokine receptor function. CRG is well-equipped for the proposed study and also benefits from access to all the facilities mentioned above.

Project members

Prof. Dr. Graeme Milligan – Professor of Molecular Pharmacology with 30 years experience in GPCR pharmacology and regulation. Currently member of the Scientific Advisory Board of three SMEs involved in the development of novel strategies to target GPCRs in a therapeutic context. More than 30 graduated PhDs Prof.

Prof. Dr. Gerard Graham – Professor of Molecular and Structural Immunology with 25 years experience of chemokine research. Currently a member of the Wellcome Trust Expert Review Group in Immunity in Health and Disease and previously a member of the Medical Research Council Infections and Immunity Board. Professor Graham is also on the scientific steering committee of Glasgow Science Centre.

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Hello everyone!
I am Noemi Karsai and I’m the next in our #ESR introduction series. I’m #ESR11 and I’m originally from Hungary, currently doing my PhD at @UoNLifeSci @COMPARE_UoBUoN, UK.

The transatlantic ECI GPCR symposium #ECIGPCR is about to start, we are ready!! Thanks to the organizers for their excellent job gathering almost 500 people across the globe! @cyclic_Andreas @NicoleAPerry1 @BenderSci @DesislavaNeshe1

My project will be focused on the role of #CXCR4/ACKR3/GRK2 -governed networks in cancer cell migration and metastasis.

Hello 🙂
I am here to continue the series in which all #ESRs are presenting themselves. I am Viviana Marolda and I am in my first year of PhD. I am #ESR13, originally from Italy, and currently, I am working as a PhD student in @CBMSO_CSIC_UAM, at Universidad Autonoma de Madrid.

Hey twitter!
I am @DehanComez. I am taking over the Oncornet account for a while to start a series of all #ESRs writing about themselves and their projects. I am #ESR5, originally from Turkey and right now I am working as a PhD student in @COMPARE_UoBUoN , @UniofNottingham , UK.

New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond https://lnkd.in/eyjrA5V

ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function: https://molpharm.aspetjournals.org/content/96/6

Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!

Hi everyone!

Public service announcement: our Marie-Curie ITN @ONCORNET1 is on Twitter! The 16 wonderful #ECRs working on the project will soon be Tweeting about #GPCR #chemokine #ECR life and #pharmacology

Please #RT & consider a follow or follow back! 🙏😀

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Contact details

Please contact us at:
info@oncornet.eu

ONCORNET Coordinator
VU University Amsterdam
The Netherlands