Griffin Discoveries
Webpage: www.griffindiscoveries.com
General description
Griffin Discoveries focuses on the discovery and development of novel GPCR-targeting drugs in areas of unmet clinical need. In addition to drug development, Griffin Discoveries also offer services to the pharmaceutical industry that address emerging GPCR drug discovery concepts such as kinetic and thermodynamic ligand profiling, receptor dimerisation and allosteric modulation. In addition to GPCR-focused research, Griffin offers in vitro assays for early ADME-tox screening, including CYP450 and hERG activity assays and microsomal stability studies that help hit and lead optimization.
Key research facilities, infrastructures and equipment
As a preclinical drug discovery company, Griffin Discoveries’ primary expertise lies in hit finding, hit optimisation and lead optimisation stages of drug development. We have broad experience in GPCR medicinal chemistry, including various targets such as histamine receptors and chemokine receptors. Griffin Discoveries is a VU University spinout company and Griffin rents laboratories from the university. This allows the use state of the art facilities, including a dedicated radionuclide centre.
Project members
- Prof. Rob Leurs
- Prof. Iwan de Esch
Follow us on
My project will be focused on the role of #CXCR4/ACKR3/GRK2 -governed networks in cancer cell migration and metastasis.
New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond https://lnkd.in/eyjrA5V
A reminder that applications for our new Deputy Editor in Chief of #PharmacologyMatters close on Monday. https://buff.ly/2PNWf4V
ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function: https://molpharm.aspetjournals.org/content/96/6
Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!
Contact details
Please contact us at:
info@oncornet.eu
ONCORNET Coordinator
VU University Amsterdam
The Netherlands