Griffin Discoveries


General description
Griffin Discoveries focuses on the discovery and development of novel GPCR-targeting drugs in areas of unmet clinical need. In addition to drug development, Griffin Discoveries also offer services to the pharmaceutical industry that address emerging GPCR drug discovery concepts such as kinetic and thermodynamic ligand profiling, receptor dimerisation and allosteric modulation. In addition to GPCR-focused research, Griffin offers in vitro assays for early ADME-tox screening, including CYP450 and hERG activity assays and microsomal stability studies that help hit and lead optimization.

Key research facilities, infrastructures and equipment
As a preclinical drug discovery company, Griffin Discoveries’ primary expertise lies in hit finding, hit optimisation and lead optimisation stages of drug development. We have broad experience in GPCR medicinal chemistry, including various targets such as histamine receptors and chemokine receptors. Griffin Discoveries is a VU University spinout company and Griffin rents laboratories from the university. This allows the use state of the art facilities, including a dedicated radionuclide centre.

Project members 

  • Prof. Rob Leurs 
  • Prof. Iwan de Esch 

Follow us on

Great way to finish the week off with some #FCS measurements of CXCR4-expressing HEK cells at @UoNLifeSci 🔬 #FluorescenceFriday

Hello everyone!
I am Noemi Karsai and I’m the next in our #ESR introduction series. I’m #ESR11 and I’m originally from Hungary, currently doing my PhD at @UoNLifeSci @COMPARE_UoBUoN, UK.

The transatlantic ECI GPCR symposium #ECIGPCR is about to start, we are ready!! Thanks to the organizers for their excellent job gathering almost 500 people across the globe! @cyclic_Andreas @NicoleAPerry1 @BenderSci @DesislavaNeshe1

Hello 🙂
I am here to continue the series in which all #ESRs are presenting themselves. I am Viviana Marolda and I am in my first year of PhD. I am #ESR13, originally from Italy, and currently, I am working as a PhD student in @CBMSO_CSIC_UAM, at Universidad Autonoma de Madrid.

Hey twitter!
I am @DehanComez. I am taking over the Oncornet account for a while to start a series of all #ESRs writing about themselves and their projects. I am #ESR5, originally from Turkey and right now I am working as a PhD student in @COMPARE_UoBUoN , @UniofNottingham , UK.

New review on #gpcr structural dynamics out in COSB. Great teamwork with the @JanaSelent group. Thanks to @Lundbeckfonden and @novonordiskfond

ONCORNET2.0 is the successor to #ONCORNET. You can see some of the work of ESRs from the first ONCORNET in this special issue of @MolPharmJournal from 2019, with reviews on #CXCR4 and #ACKR3 structure and function:

Hi everyone – we’re on Twitter! ONCORNET2.0 is a #MarieCurie ITN of 16 ESRs across Europe studying #chemokine #GPCRs #CXCR4 and #ACKR3 in cancer. Our projects cover molecular dynamics, medchem, #pharmacology through to translational work. Follow us for updates from our ESRs!

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Contact details

Please contact us at:

ONCORNET Coordinator
VU University Amsterdam
The Netherlands