University of Nottingham
The University of Nottingham has over 32,000 students and 1,400 academic staff. In the 2008 Research Assessment Exercise, 90 per cent of research at Nottingham was judged to be of an ‘international standard’ and 60 per cent ‘world-leading’. The Cell Signalling Research Group (CSRG) and the Centre of Biomolecular Sciences (CBS) at the University of Nottingham has a world-class reputation for the study of GPCRs. The group consists of ~25 researchers engaged in drug discovery and applying single cell and single molecule imaging techniques, medicinal chemistry and in vivo cardiovascular approaches to the study of ligand-receptor binding, intracellular signalling and protein-protein interactions involving GPCRs.
Key research facilities, infrastructures and equipment
CSRG has state-of-the-art facilities for the imaging of single cells and has developed novel fluorescent ligand technologies for the study of GPCRs at the single cell and single molecule level. Dedicated equipment includes five Zeiss confocal systems (LSM510, LSM710, Confocor 3, Confocor 2, Exciter), a DeltaVision for fast widefield deconvolution imaging, and facilities for high content screening (Image Express Ultra), TIRF, fluorescence correlation spectroscopy, FLIM, FRET and bimolecular fluorescence complementation. CSRG has extensive experience and facilities for GPCR molecular pharmacology, in vivo cardiovascular monitoring and drug discovery. CBS has state-of-the-art facilities for medicinal chemistry and molecular modelling.