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Marie Skłodowska-Curie Action
Innovative Training Networks (ITN)

2020-2024

 

Funded by

marie curie actions   Marie Curie Actions

 

 

unnamed   
EU Horizon 2020

 

 

european union logo   European Union

 

Pharmacological analysis of photoactivatable CXCR4/ACKR3 ligands in vitro/in vivo

 

Early stage researcher 7 (ESR7) project

Supervision: Prof. Dr. Rob Leurs, Dr. Henry Vischer, Dr. Maikel Wijtmans

Host: Vrije Universiteit Amsterdam

 

I- Project proposal:
Aim:

The project aims for the development of photopharmacological approaches for the CXCR4 and ACKR3 chemokine receptors. New assays to dynamically modulate these chemokine receptor systems with light-switchable ligands will be developed. Main focus will be on in vitro, cell-based assays, but ultimately light-induced in vivo modulation of CXCR4 and/or ACKR3 function is the final aim within this project.

  

Methodology:

This project will entail the assay development of new photopharmacology assays to evaluate photoswitchable small-molecule CXCR4 and ACKR3 ligands (agonists/antagonists). The characterization of new photoswitchable ligands can be supported by computer-aided drug design and GPCR mutation studies where necessary. Design and synthesis of photoswitchable ligands will be conducted by fellow ESR1.

 

Planned secondments:

InterAx (Switserland) - candidate will get exposed to relevant dynamic cell-based assays.

INSERM (Paris, France) - candidate will work on biological characterization of photoswitchables compounds in relevant models of disease. 

 

II - Requirement candidate:

Required diploma: A MSc degree in Biochemistry or Pharmacology or related Biomedical degrees

Required expertise: The candidate has a strong background (theoretical and practical) in cell biology, signal transduction and preferably pharmacology and/or molecular biology.

Recommended expertise: Expertise in GPCR molecular and cellular pharmacology is a strong pre. Previous experience with biosensor-based assay development and/or photopharmacology is also highly valued

 

Key publications:

  1. Hauwert et al., J. Am. Chem. Soc. 2018, 140, 4232
  2. Hauwert et al., Angew. Chem. Intl. Ed. 2019, 58, 4531
  3. Gómez-Santacana et al., Angew. Chem. Intl. Ed. 2018, 57, 11608
  4. Gómez-Santacana et al., Beilstein Arch. 2019, doi:10.3762/bxiv.2019.69.v1 

 

For more information:

Prof. Dr. Rob Leurs - This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Henry Vischer - This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Maikel Wijtmans - This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Application:

Apply here

Lijndik